CD44 Orchestrates Metastatic Teamwork.

CD44 Orchestrates Metastatic Teamwork CD44 Orchestrates Metastatic Teamwork. Dev Cell. 2018 Dec 17 PMID: 30562512

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

Castaño Z, San Juan BP, Spiegel A, Pant A, DeCristo MJ, Laszewski T, Ubellacker JM, Janssen SR, Dongre A, Reinhardt […]

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai […]

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr AJ, Burdziak C, Moon KR, Chaffer CL, Pattabiraman […]

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova […]

EMT, cell plasticity and metastasis

Chaffer CL, San Juan BP, Lim E, Weinberg RA. (2016) EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 35(4):645-654 PMID: […]

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic ND, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. […]

Poised with purpose: cell plasticity enhances tumorigenicity

Marjanovic ND, Weinberg RA, Chaffer CL. (2013). Poised with purpose: cell plasticity enhances tumorigenicity. Cell Cycle. 12(17):2713-4 PMID: 23966153 PMCID: […]

Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity

Chaffer CL, Marjanovic ND, Lee TI, Bell G, Kleer CG, Reinhardt F, D’Alessio AC, Young RA, Weinberg RA. (2013) Poised […]

Formation and maintenance of mesenchymal and stem-cell states in the breast by paracrine and autocrine signals

Scheel C, Ng Eaton E, Li SHJ, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Richardson AL, Weinberg […]

Normal and neoplastic epithelial cells can spontaneously dedifferentiate to a stem-like state

Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Reinhardt F, Su Y, Polyak K, Arendt LM, […]

A perspective on cancer cell metastasis

Chaffer CL, and Weinberg RA. (2011). A perspective on cancer cell metastasis. Science. 331(6024):1559-64 Science. 2011 Mar 25;331(6024):1559-64. doi: 10.1126/science.1203543.

Mesenchymal to epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2

Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. (2006). Cancer Research. 66:11271-8 PMID: 17145872 DOI: 10.1158/0008-5472.CAN-06-2044